Description

1-(2-Fluoro-Ethoxy)-4-Iodo-Benzene is a high-purity fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining a fluoroethoxy side chain with an iodine substituent, which provides versatile handles for further functionalization via cross-coupling reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the fluorine and iodine atoms can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in transition metal catalysis.
• Material Science: Employed in the synthesis of organic electronic materials and liquid crystals, where the fluoroethoxy group can influence dielectric properties.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, enabling rapid molecular diversification.
• Radiolabeling Precursor: The iodine-127 present can be a non-radioactive analog for developing protocols for radioiodinated (e.g., I-125) compounds used in medical imaging and therapy.

Basic Information

Item	Details
Product Name	1-(2-Fluoro-Ethoxy)-4-Iodo-Benzene
CAS No.	132837-05-9
Molecular Formula	C8H8FIO
Molecular Weight	266.05 g/mol
Synonyms	4-Iodo-1-(2-fluoroethoxy)benzene; 1-Fluoro-2-(4-iodophenoxy)ethane; p-Iodophenyl 2-fluoroethyl ether; 2-(4-Iodophenoxy)-1-fluoroethane; 4-Iodophenoxyethyl fluoride; 132837-05-9; 1-(2-Fluoroethoxy)-4-iodobenzene
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-Ethoxy)-4-Iodo-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.