Description

(n-Acetyl)-(4R)-Benzyl-2-Oxazolidinone CAS NO 132836-66-9 is a high-purity chiral auxiliary and synthetic intermediate of significant importance in asymmetric organic synthesis. Its core value lies in enabling the stereoselective construction of complex molecules, a critical requirement for developing active pharmaceutical ingredients (APIs) and advanced fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality building blocks for their synthetic workflows.

Application

• Asymmetric Synthesis: Serves as a versatile chiral auxiliary for the enantioselective alkylation, aldol, and Diels-Alder reactions.
• Pharmaceutical Intermediate: A key building block in the synthesis of chiral drugs, particularly those targeting central nervous system (CNS) disorders and cardiovascular diseases.
• Agrochemical Development: Used in the research and production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Catalyst and Ligand Preparation: Acts as a precursor for novel chiral catalysts and ligands used in homogeneous catalysis.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic chemistry laboratories and pilot-scale process optimization.
• Fine Chemical Synthesis: Employed in the manufacture of complex, high-value specialty chemicals and flavors & fragrances requiring specific stereochemistry.

Basic Information

Product Name	(n-Acetyl)-(4R)-Benzyl-2-Oxazolidinone
CAS No.	132836-66-9
Molecular Formula	C13H15NO3
Molecular Weight	233.26 g/mol
Synonyms	(4R)-4-Benzyl-3-acetyl-2-oxazolidinone; (R)-4-Benzyl-3-acetyloxazolidin-2-one; N-Acetyl-4(R)-benzyl-2-oxazolidinone; (R)-N-Acetyl-4-benzyl-2-oxazolidinone; Evans Chiral Auxiliary Derivative; (R)-3-Acetyl-4-benzyloxazolidin-2-one; (4R)-Benzyl-3-acetyl-1,3-oxazolidin-2-one
EINECS	Contact for details

Quality Control

Our (n-Acetyl)-(4R)-Benzyl-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for sensitive asymmetric synthesis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment. We support cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.