Description

3,4-Difluoromandelic Acid is a high-purity fluorinated mandelic acid derivative, serving as a critical chiral building block and synthetic intermediate. Its value lies in the strategic incorporation of fluorine atoms, which can dramatically alter the physicochemical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Building block for creating advanced herbicides and pesticides where fluorine substitution enhances activity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: Versatile starting material for exploring new fluorination strategies and structure-activity relationships (SAR) in medicinal chemistry.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex fluorinated fine chemicals and specialty materials.

Basic Information

Product Name	3,4-Difluoromandelic Acid
CAS No.	132741-29-8
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	2-(3,4-Difluorophenyl)-2-hydroxyacetic Acid; (3,4-Difluorophenyl)(hydroxy)acetic Acid; DL-3,4-Difluoromandelic Acid; (±)-3,4-Difluoromandelic Acid; 3,4-DFMA; α-Hydroxy-3,4-difluorophenylacetic Acid
EINECS	Contact for details

Quality Control

Our 3,4-Difluoromandelic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.