Description

Insulin-Like Growth Factor Ii, Leu(27)- CAS NO 132729-29-4 is a synthetic analog of Insulin-like Growth Factor II (IGF-II), a key peptide hormone involved in growth and development. This modified form, featuring a leucine substitution at position 27, is critical for advanced biochemical and pharmaceutical research due to its specific biological activity and stability profile. It is an essential reagent for researchers and developers in the fields of endocrinology, metabolic disease studies, and biopharmaceutical development.

Application

• Biochemical Research: Used as a high-purity reference standard and active agent in studies of IGF receptor signaling pathways and cellular growth mechanisms.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the preclinical development of novel therapeutics targeting growth disorders and metabolic diseases.
• Cell Culture & Tissue Engineering: Employed as a growth factor supplement in specialized cell culture media to promote the proliferation and differentiation of specific cell types.
• Diagnostic Assay Development: Utilized in the calibration and development of immunoassays (e.g., ELISA) and other diagnostic kits for measuring IGF-II levels in biological samples.
• Metabolic Studies: Applied in research models to investigate the role of IGF-II in glucose metabolism, insulin sensitivity, and related metabolic processes.

Basic Information

Product Name	Insulin-Like Growth Factor Ii, Leu(27)-
CAS No.	132729-29-4
Molecular Formula	C390H620N112O118S8
Molecular Weight	~ 8.9 kDa
Synonyms	Leu27-IGF-II; IGF-II (Leu27); Insulin-like Growth Factor 2, Leu(27) analog; [Leu27]IGF-II; Somatomedin A, Leu(27) variant; IGF-2 Leu27; Recombinant Human IGF-II (Leu27); [Leu27]-IGF-2
EINECS	Contact for details

Quality Control

Our Insulin-Like Growth Factor Ii, Leu(27)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and peptide mapping for identity confirmation, to ensure it meets high-purity research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, biological activity (where applicable), and endotoxin levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Contact for details
Endotoxin	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.