Description

(Leu31,Pro34)-Neuropeptide Y (Human, Rat) CAS NO 132699-73-1 is a synthetic peptide analog of Neuropeptide Y (NPY), a potent neuromodulator involved in numerous physiological processes. This specific analog, featuring leucine and proline substitutions at positions 31 and 34, is a critical research tool for studying NPY receptor subtype selectivity, particularly the Y1 receptor, and its role in energy homeostasis, cardiovascular function, and anxiety. It is essential for academic, pharmaceutical, and biotechnology researchers focused on neuroendocrinology, metabolic disorders, and central nervous system drug discovery. The compound's high purity and specificity make it indispensable for in vitro binding assays, functional studies, and structure-activity relationship (SAR) analysis.

Application

• Neuroscience Research: Investigation of Neuropeptide Y (NPY) signaling pathways, receptor binding affinity (Y1, Y2, Y4, Y5), and neuronal communication.
• Metabolic Disorder Studies: Research into the role of NPY in appetite regulation, obesity, diabetes, and energy balance using this Y1 receptor-preferring ligand.
• Cardiovascular Pharmacology: Functional analysis of NPY's effects on blood pressure, heart rate, and vascular tone.
• Drug Discovery & Development: Serving as a reference standard and pharmacological tool for screening and developing novel therapeutics targeting NPY receptors.
• Biochemical Assays: Use in competitive binding assays (e.g., radioligand binding), cAMP accumulation assays, and calcium mobilization studies to characterize receptor activity.
• Academic & Institutional Research: Fundamental research in physiology, endocrinology, and behavioral studies related to stress, anxiety, and feeding behavior.

Basic Information

Product Name	(Leu31,Pro34)-Neuropeptide Y (Human, Rat)
CAS No.	132699-73-1
Molecular Formula	C190H287N55O57S
Molecular Weight	4253.7 g/mol
Synonyms	[Leu31, Pro34] Neuropeptide Y; [Leu31,Pro34]-NPY; NPY (Leu31,Pro34); h/r[Leu31,Pro34]NPY; Neuropeptide Y (Leu31,Pro34) (human, rat); [Leu31,Pro34]-Neuropeptide Y; NPY, [Leu31,Pro34]-; NPY Y1 receptor agonist analog
EINECS	Contact for details

Quality Control

Our (Leu31,Pro34)-Neuropeptide Y is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, peptide content, and solubility data to support your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the lyophilized powder desiccated. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solubility	Soluble in water, acetic acid, or DMSO
Amino Acid Composition	Within ± 10% of theoretical values

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.