Description

Fmoc-L-tert-Leucine CAS NO 132684-60-7 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its value lies in the unique steric bulk of the tert-leucine side chain, which is prized for inducing specific conformational changes and enhancing the metabolic stability of synthetic peptides and peptidomimetics. This building block is critically needed by pharmaceutical R&D teams, biotechnology companies, and CROs/CMOs developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Peptide Synthesis: A key intermediate in the Fmoc-SPPS production of therapeutic peptides targeting GPCRs, hormones, and antimicrobial agents.
• Peptidomimetic Drug Design: Incorporation into non-natural peptide backbones to improve bioavailability, proteolytic stability, and target binding affinity.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Bioconjugation & Probe Development: Serves as a building block for creating labeled peptides, affinity tags, and molecular imaging probes.
• Academic & Institutional Research: Fundamental research tool in biochemistry and structural biology for studying protein folding and protein-protein interactions.
• Contract Manufacturing: Essential raw material for CDMOs specializing in the GMP-scale production of peptide Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Fmoc-L-tert-Leucine
CAS No.	132684-60-7
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-L-tert-leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine; Fmoc-Tle-OH; Fmoc-3-methyl-L-valine; Nα-Fmoc-L-tert-leucine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3,3-dimethylbutanoic acid; Fmoc-L-t-butylglycine; N-Fmoc-L-tert-leucine
EINECS	Contact for details

Quality Control

Our Fmoc-L-tert-Leucine is manufactured under strict quality management systems to ensure batch-to-batch consistency suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to relevant ICH guidelines, and our quality systems support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.