Description

2-Azetidinecarboxamide, 1-Acetyl-N-Methyl-, (S)- (9Ci) is a high-purity, chiral azetidine derivative, a crucial building block in advanced organic synthesis. Its value lies in its defined stereochemistry and functionalized azetidine ring, which is integral to constructing complex molecules with targeted biological activity. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry, particularly in the development of novel drug candidates and bioactive probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Protease Inhibitor Synthesis: Serves as a precursor in the synthesis of inhibitors targeting specific enzymes, leveraging the azetidine ring's mimicry of transition states.
• Peptidomimetics Development: Incorporated into peptide analogs to enhance metabolic stability and membrane permeability while maintaining biological activity.
• Ligand and Catalyst Preparation: Utilized in the preparation of specialized chiral ligands and organocatalysts for asymmetric synthesis.
• Academic and Industrial R&D: Employed in chemical biology and discovery chemistry programs within academic institutions and corporate research laboratories.

Basic Information

Product Name	2-Azetidinecarboxamide, 1-Acetyl-N-Methyl-, (S)- (9Ci)
CAS No.	132663-36-6
Molecular Formula	C7H12N2O2
Molecular Weight	156.18 g/mol
Synonyms	(S)-1-Acetyl-N-methylazetidine-2-carboxamide; N-Methyl-1-acetylazetidine-2-carboxamide, (S)-; 1-Acetyl-N-methyl-(S)-2-azetidinecarboxamide; L-1-Acetyl-N-methylazetidine-2-carboxamide; Azetidine-2-carboxamide, 1-acetyl-N-methyl-, (2S)-; (2S)-1-Acetyl-N-methylazetidine-2-carboxamide; 132663-36-6; (S)-Azetidine-2-carboxamide, 1-acetyl-N-methyl-
EINECS	Contact for details

Quality Control

Our 2-Azetidinecarboxamide, 1-Acetyl-N-Methyl-, (S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.