Description

Neurogranin is a neuron-specific, postsynaptic protein that plays a critical role in synaptic plasticity and calcium-mediated signal transduction. Its importance lies in its function as a key regulator of calmodulin availability and as a biomarker for synaptic integrity and neurodegenerative processes. This makes it an essential reagent for researchers and developers in the fields of neuroscience, biomarker discovery, and pharmaceutical development, particularly for studies related to Alzheimer's disease, cognitive function, and neuropsychiatric disorders.

Application

• Biomarker Research: Used as a quantitative biomarker in cerebrospinal fluid (CSF) and blood plasma studies for synaptic dysfunction in Alzheimer's disease and other dementias.
• Neuroscience & Cell Biology: Essential reagent for investigating synaptic plasticity, learning, memory mechanisms, and postsynaptic signaling pathways.
• Diagnostic Kit Development: Serves as a critical antigen and standard in the development and calibration of immunoassays (ELISA, Luminex) for clinical diagnostics.
• Drug Discovery & Validation: Used in target validation and screening assays for novel therapeutics aimed at modulating synaptic function and treating cognitive decline.
• Academic & Preclinical Studies: Fundamental tool for in vitro and in vivo studies exploring the molecular basis of neurological and psychiatric conditions.
• Quality Control Reference: Acts as a reference standard for ensuring the accuracy and consistency of commercial and in-house biomarker assays.

Basic Information

Product Name	Neurogranin
CAS No.	132654-77-4
Molecular Formula	C202H336N56O64S
Molecular Weight	4550.4 g/mol
Synonyms	Neurogranin; Protein Neurogranin; RC3; p17; Neuromodulin; BICKS; Ng; Neurogranin (78 aa); Neurogranin, human; Neurogranin, rat; Neurogranin, recombinant
EINECS	Contact for details

Quality Control

Our Neurogranin is produced under stringent conditions to ensure the highest levels of purity and biological activity, suitable for sensitive research and diagnostic applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and functional activity assays. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability, consistency, and compliance with relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Upon reconstitution, aliquot and store at ≤ -70°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 95%
Molecular Weight	4550.4 ± 2 Da
Endotoxin Level	< 1.0 EU/μg
Biological Activity	Assessed by immunoassay binding
Solubility	Soluble in aqueous buffers
Residual Moisture (KF)	< 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.