Description

2-Bromo-2-Fluoropropionic Acid is a versatile fluorinated and brominated organic acid building block. This bifunctional compound is valued for its unique reactivity, serving as a key intermediate in the synthesis of complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to introduce fluorine and bromine motifs, which are critical for modulating biological activity and material properties.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and brominated side chains to enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, where the fluorine atom can improve lipophilicity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated components used in display technologies and organic light-emitting diodes.
• Peptide Modification & Bioconjugation: Employed to introduce halogenated handles into peptides and proteins for further functionalization or as probes in biochemical research.
• Polymer Chemistry: Acts as a monomer or modifier for creating specialty fluoropolymers with unique surface properties and chemical resistance.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.

Basic Information

Product Name	2-Bromo-2-Fluoropropionic Acid
CAS No.	132629-22-2
Molecular Formula	C3H4BrFO2
Molecular Weight	170.96 g/mol
Synonyms	2-Bromo-2-fluoropropanoic acid; α-Bromo-α-fluoropropionic acid; 2-Fluoro-2-bromopropionic acid; Propanoic acid, 2-bromo-2-fluoro-; 2-Bromo-2-fluoropropanoate; NSC 405124; B2FPA
EINECS	Contact for details

Quality Control

Our 2-Bromo-2-Fluoropropionic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, store separately from incompatible materials. Use appropriate corrosion-resistant containers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.