Description

Boc-L-β-Homoleucine CAS NO 132549-43-0 is a protected, non-proteinogenic amino acid derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptides and peptidomimetics with enhanced metabolic stability and bioavailability. This high-purity intermediate is essential for research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on novel drug discovery, peptide-based therapeutics, and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to incorporate modified amino acid residues into peptide chains to improve stability, potency, and pharmacokinetic properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the development of protease inhibitors and other targeted therapeutics.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the Fmoc/t-Boc strategy in automated peptide synthesis.
• Chemical Biology Probes: Used to create labeled or tagged amino acid analogs for studying biological pathways and protein function.

Basic Information

Product Name	Boc-L-β-Homoleucine
CAS No.	132549-43-0
Molecular Formula	C₁₂H₂₃NO₄
Molecular Weight	245.32 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-4-methylhexanoic acid; Boc-β-hLeu-OH; N-(tert-Butoxycarbonyl)-L-β-homoleucine; Boc-L-β-Homoleucine; tert-Butyloxycarbonyl-L-β-homoleucine; N-Boc-L-β-homoleucine; (S)-2-(tert-Butoxycarbonylamino)-4-methylhexanoic acid; L-β-Homoleucine, N-Boc derivative
EINECS	Contact for details

Quality Control

Our Boc-L-β-Homoleucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to cGMP guidelines where applicable to support our customers in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.