Description

Angiotensin I, (β-(4-Pyridyl-1-Oxide)-Ala(4))- is a chemically modified peptide analog of Angiotensin I, designed for advanced biochemical and pharmacological research. This compound is critical for studying the renin-angiotensin system (RAS), a key regulator of blood pressure and fluid balance. It serves as a valuable tool for researchers and developers in pharmaceutical discovery, proteomics, and cardiovascular disease modeling, enabling precise investigation of enzyme interactions and receptor binding mechanisms.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in enzymatic assays to study angiotensin-converting enzyme (ACE) and related proteases.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the development of novel cardiovascular therapeutics and diagnostic agents.
• Proteomics & Peptide Mapping: Employed in mass spectrometry and chromatography studies for method development and system calibration.
• Cell Signaling Studies: Applied in vitro to investigate the pathways and physiological effects mediated by the renin-angiotensin system.
• Academic Research: Utilized in university and institutional labs for fundamental research into hypertension, heart failure, and renal function.
• Quality Control Reference: Acts as a high-purity certified reference material (CRM) for analytical method validation in QC laboratories.

Basic Information

Product Name	Angiotensin I, (β-(4-Pyridyl-1-Oxide)-Ala(4))-
CAS No.	132488-66-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	[Des-Asp1]-Angiotensin I (4-Pyridyl-1-oxide-βAla4 analog); Angiotensin I (4-β-(4-Pyridyl-1-oxide)alanine) analog; (β-(4-Pyridyl-1-Oxide)-Ala4)-Angiotensin I; Pyridyloxide-Ala4-Angiotensin I; Modified Angiotensin I peptide; ACE research peptide 132488-66-5
EINECS	Contact for details

Quality Control

Our Angiotensin I, (β-(4-Pyridyl-1-Oxide)-Ala(4))- is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for laboratory chemicals, and specifications can be aligned with relevant pharmacopeial guidelines for reference standard qualification upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For extended storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in DMSO, Acetic Acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.