Description

α-Methyl-4-(4-Butyl-2-Thiazolyl)Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with significant commercial and research value. This compound is a critical building block in the synthesis of more complex active pharmaceutical ingredients (APIs), particularly those targeting inflammation and pain. It is essential for pharmaceutical R&D laboratories and manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of non-steroidal anti-inflammatory drugs (NSAIDs).
• API Synthesis: Core building block for the development and production of proprietary anti-inflammatory and analgesic active pharmaceutical ingredients.
• Biochemical Research: Used in pharmacological studies to investigate cyclooxygenase (COX) inhibition pathways and structure-activity relationships.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production runs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and novel drug discovery.

Basic Information

Product Name	α-Methyl-4-(4-Butyl-2-Thiazolyl)Benzeneacetic Acid
CAS No.	132483-55-7
Molecular Formula	C₁₆H₁₉NO₂S
Molecular Weight	289.39 g/mol
Synonyms	2-(4-(4-Butyl-2-thiazolyl)phenyl)propanoic acid; α-Methyl-4-(4-butyl-2-thiazolyl)benzeneacetic acid; 4-(4-Butyl-2-thiazolyl)-α-methylbenzeneacetic acid; 2-[4-(4-Butyl-1,3-thiazol-2-yl)phenyl]propanoic acid; (RS)-2-(4-(4-Butylthiazol-2-yl)phenyl)propionic acid; Arylthiazole acetic acid derivative; NSAID thiazole intermediate
EINECS	Contact for details

Quality Control

Our α-Methyl-4-(4-Butyl-2-Thiazolyl)Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific pharmacopeial or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.