Description

Terikalant is a selective and potent small molecule inhibitor of the G protein-coupled inwardly rectifying potassium (GIRK) channel. This compound is a critical research tool for studying cardiac electrophysiology, atrial fibrillation, and neuronal signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on ion channel biology and cardiovascular or neurological drug discovery.

Application

• Cardiac Electrophysiology Research: Used to study the role of GIRK channels in heart rate regulation and atrial excitability.
• Atrial Fibrillation (AF) Models: A key pharmacological agent in preclinical research for investigating novel antiarrhythmic mechanisms targeting the IKACh current.
• Neuroscience & Neuropharmacology: Employed to probe the function of neuronal GIRK channels in synaptic transmission, pain pathways, and substance abuse disorders.
• High-Throughput Screening (HTS): Serves as a reference compound and positive control in assays designed to discover new GIRK channel modulators.
• Biochemical & Cellular Assay Development: Used to validate and optimize new assay platforms for measuring GIRK channel activity.

Basic Information

Product Name	Terikalant
CAS No.	132338-79-5
Molecular Formula	C20H22N4O3S
Molecular Weight	398.48 g/mol
Synonyms	Terikalant; N-[2-(4-Pyridinyl)phenyl]-1,2,3,4-tetrahydro-1-naphthalenesulfonamide; VU573; GIRK Channel Blocker; IKACh Inhibitor; Atrial-Selective Antiarrhythmic Agent; Benzene sulfonamide, N-[2-(4-pyridinyl)phenyl]-1,2,3,4-tetrahydro-1-naphthalenyl-
EINECS	Contact for details

Quality Control

Every batch of Terikalant is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our standard material meets a typical purity specification of ≥98% (by HPLC). Comprehensive analytical data, including HPLC chromatograms and NMR spectra, are documented in the accompanying Certificate of Analysis (COA), which is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.