Description

o-Desmethylnaftopidil is a key pharmaceutical intermediate and reference standard of significant importance in medicinal chemistry and analytical research. Its primary value lies in its role as a major metabolite of Naftopidil, a selective α-1 adrenergic receptor antagonist, making it critical for pharmacokinetic studies and drug development. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on urology and cardiovascular therapeutics, who require high-purity materials for synthesis, bioanalysis, and quality control.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and development of Naftopidil and related therapeutic agents.
• Metabolite Reference Standard: Used as an analytical standard in HPLC, LC-MS, and other chromatographic methods for quantifying drug metabolites in biological matrices during pharmacokinetic studies.
• Biochemical Research: Employed in in-vitro studies to investigate the metabolic pathways, efficacy, and safety profile of α-blocker drugs.
• Quality Control & Assurance: Serves as a certified reference material (CRM) for the identification and purity assessment of active pharmaceutical ingredients (APIs) in pharmaceutical manufacturing.
• Impurity Profiling: Used to identify, characterize, and control process-related impurities and degradation products in Naftopidil drug substance and finished dosage forms.

Basic Information

Product Name	o-Desmethylnaftopidil
CAS No.	132194-30-0
Molecular Formula	C₂₄H₂₈N₂O₃
Molecular Weight	392.49 g/mol
Synonyms	2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl 1-naphthoate; Naftopidil Impurity C; Naftopidil Metabolite; N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-1-naphthalenecarboxamide; Desmethyl Naftopidil; O-Desmethyl Naftopidil; Naftopidil Related Compound C
EINECS	Contact for details

Quality Control

Our o-Desmethylnaftopidil is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR, MS) and purity determination by advanced chromatographic techniques (HPLC). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.