Description

Carbamazepine-D10 is a deuterium-labeled analog of the anticonvulsant and mood-stabilizing drug carbamazepine, specifically identified by CAS NO 132183-78-9. This stable isotope-labeled compound is an essential internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology professionals who require precise measurement of carbamazepine levels in biological matrices.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of carbamazepine in plasma, serum, and urine.
• Pharmacokinetic & Metabolism Research: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in both preclinical and clinical studies.
• Therapeutic Drug Monitoring (TDM): Used in the development and validation of assays to monitor carbamazepine concentrations in patient samples for dose optimization and toxicity prevention.
• Forensic & Clinical Toxicology: Supports accurate identification and quantification of carbamazepine in cases of overdose or compliance testing.
• Drug Impurity & Metabolite Profiling: Aids in the characterization and quantification of drug-related impurities and metabolites during pharmaceutical development.
• Reference Material for Calibration: Serves as a high-purity certified reference material (CRM) for calibrating analytical instruments and validating methods.

Basic Information

Product Name	Carbamazepine-D10
CAS No.	132183-78-9
Molecular Formula	C15H2D10N2O
Molecular Weight	246.33 g/mol
Synonyms	5H-Dibenzo[b,f]azepine-5-carboxamide-10,11-D10; Deuterated Carbamazepine; Carbamazepine-d10; 5-Carbamoyl-5H-dibenzo[b,f]azepine-10,11-D10; Tegretol-D10 (labeled analog); CBZ-D10; 10,11-Dideuterio-5H-dibenzo[b,f]azepine-5-carboxamide
EINECS	Contact for details

Quality Control

Our Carbamazepine-D10 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is analyzed to confirm identity, purity (by HPLC), isotopic enrichment (by MS), and the absence of interfering impurities. A comprehensive Certificate of Analysis (COA) detailing batch-specific results, including chromatographic data and NMR confirmation, is provided to guarantee traceability and compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.