Description

2-Amino-5-Iodobenzonitrile is a versatile halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a nitrile group ortho to an iodine atom, makes it a valuable precursor for constructing complex heterocyclic systems and functionalized aromatic compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogen and nitrile functionality.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Dye and Pigment Synthesis: Utilized as an intermediate in the production of specialized dyes and pigments due to its amino and cyano groups.
• Chemical Biology Probes: Acts as a building block for creating fluorescent tags, affinity labels, and other molecular probes for biochemical research.

Basic Information

Item	Details
Product Name	2-Amino-5-Iodobenzonitrile
CAS No.	132131-24-9
Molecular Formula	C7H5IN2
Molecular Weight	244.03 g/mol
Synonyms	5-Iodo-2-aminobenzonitrile; 2-Amino-5-iodobenzene carbonitrile; 5-Iodoanthranilonitrile; Benzonitrile, 2-amino-5-iodo-; 2-Cyano-4-iodoaniline; 4-Iodo-2-cyanobenzenamine
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Iodobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.