Description

Mu Conotoxin Giiia, 4-Azidosalicylyl- CAS NO 132035-35-9 is a chemically modified, photoactivatable derivative of the μ-conotoxin GIIIA, a potent and selective peptide antagonist of voltage-gated sodium channels. This derivative is engineered for advanced biochemical research, enabling covalent cross-linking studies to map receptor binding sites and investigate channel pharmacology. It is an essential tool for neuroscientists, pharmacologists, and biochemists in academic, pharmaceutical, and biotechnology sectors engaged in ion channel research, neurotoxin studies, and drug discovery.

Application

• Photoaffinity Labeling: Covalent tagging of voltage-gated sodium channels (NaV channels) for structural and binding site analysis.
• Biochemical Research: Investigation of sodium channel subtype specificity, function, and inhibition mechanisms.
• Neuroscience Tool: Precise probing of neuronal signaling pathways and action potential generation in research models.
• Drug Discovery Platform: Target validation and high-throughput screening for novel analgesic and neuroprotective compounds.
• Toxin-Receptor Interaction Studies: Mapping the interaction interface between conotoxins and their ion channel targets.
• Proteomic Analysis: Identification and isolation of sodium channel proteins and associated complexes from tissue samples.

Basic Information

Product Name	Mu Conotoxin Giiia, 4-Azidosalicylyl-
CAS No.	132035-35-9
Molecular Formula	C96H147N33O27S6
Molecular Weight	~2299.7 g/mol
Synonyms	4-Azidosalicylyl-μ-Conotoxin GIIIA; μ-Conotoxin GIIIA, 4-Azidosalicylamide derivative; Photoactivatable μ-Conotoxin GIIIA; μ-CTX GIIIA aryl azide; NaV channel photoaffinity probe; Mu-Conotoxin GIIIA azidosalicylate; Peptide neurotoxin derivative; Sodium channel antagonist probe
EINECS	Contact for details

Quality Control

Every batch of Mu Conotoxin Giiia, 4-Azidosalicylyl- is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Our quality assurance includes comprehensive analytical testing via HPLC and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and peptide content.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Biological Activity	Inhibits NaV1.4 channels (IC50 provided on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.