Description

Boc-L-3-Nitrophenylalanine CAS NO 131980-29-5 is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) derivative of L-3-nitrophenylalanine. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, where it introduces a nitro-substituted aromatic side chain for further chemical modification. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the controlled, sequential assembly of custom peptides containing nitro-phenylalanine residues.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile intermediate for creating targeted libraries of novel compounds for screening against various biological targets.
• Bioconjugation & Probe Development: The nitro group provides a handle for reduction to an amine, enabling subsequent labeling with fluorescent dyes, biotin, or other reporter molecules.
• Process Chemistry & API Manufacturing: Used in the scalable synthesis of peptide-based therapeutics where the Boc protecting group strategy is employed.
• Academic & Industrial Research: Fundamental studies in organic synthesis, asymmetric catalysis, and the exploration of structure-activity relationships (SAR).

Basic Information

Product Name	Boc-L-3-Nitrophenylalanine
CAS No.	131980-29-5
Molecular Formula	C14H18N2O6
Molecular Weight	310.30 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-nitrophenyl)propanoic acid; N-(tert-Butoxycarbonyl)-3-nitro-L-phenylalanine; Boc-3-NO2-Phe-OH; Boc-L-Phe(3-NO2)-OH; N-Boc-3-nitro-L-phenylalanine; tert-Butyl (S)-(1-((3-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (alternative representation); BOC-L-3-Nitro-phenylalanine; Nα-Boc-3-nitro-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Boc-L-3-Nitrophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing specific results for purity, appearance, and identity are provided to ensure compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.