Description

Cefepime-D8 Sulfate is a deuterated internal standard of the fourth-generation cephalosporin antibiotic, cefepime, specifically labeled with eight deuterium atoms. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative mass spectrometry-based analyses in pharmaceutical research and quality control. It is primarily used by analytical laboratories and pharmaceutical companies engaged in method development, pharmacokinetic studies, and impurity profiling for cefepime and related compounds.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise and accurate quantification of cefepime in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioavailability Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Quality Control (QC): Used in assay development and validation to determine the potency and purity of cefepime active pharmaceutical ingredient (API) and finished drug products.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of cefepime metabolites in in vitro and in vivo studies.
• Regulatory Compliance and Method Validation: Supports analytical methods that comply with guidelines from regulatory bodies (e.g., FDA, EMA) requiring stable isotope-labeled internal standards.
• Forensic and Anti-Doping Analysis: Facilitates the detection and confirmation of cefepime in forensic toxicology and sports doping control.

Basic Information

Product Name	Cefepime-D8 Sulfate
CAS No.	131857-33-5
Molecular Formula	C19H17D8N6O5S2 • H2SO4 (or related salt form)
Molecular Weight	Contact for details
Synonyms	(6R,7R)-7-[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate-d8 Sulfate; 1-[[(6R,7R)-7-[(2Z)-2-(2-Amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium-d8 Sulfate; Cefepime-d8; BMY-28142-d8; Maxipime-d8
EINECS	Contact for details

Quality Control

Every batch of Cefepime-D8 Sulfate is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment suitable for sensitive analytical applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, purity (by HPLC), isotopic purity (by MS), and other critical parameters to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.