Description

1-[[(6R,7R)-7-Amino-2-Carboxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-3-Yl]Methyl]-1-Methylpyrrolidinium-D3 Chloride is a high-purity, deuterium-labeled advanced pharmaceutical intermediate of significant importance in modern drug development and research. This compound is specifically designed for use in the synthesis of deuterated active pharmaceutical ingredients (APIs), which can offer improved metabolic stability and pharmacokinetic profiles. It is an essential building block for researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing novel cephalosporin antibiotics and other therapeutic agents.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: A key intermediate for creating deuterium-labeled versions of cephalosporin antibiotics and other drugs to enhance metabolic stability and extend patent life.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new drug candidates with optimized properties.
• Metabolic Pathway Tracing: Serves as a stable isotope-labeled internal standard in mass spectrometry for accurate quantification and metabolic studies in pharmacokinetic research.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for deuterated pharmaceuticals under GMP conditions.
• Reference Standard Production: Used to manufacture certified reference standards for quality control and regulatory compliance in pharmaceutical analysis.

Basic Information

Product Name	1-[[(6R,7R)-7-Amino-2-Carboxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-3-Yl]Methyl]-1-Methylpyrrolidinium-D3 Chloride
CAS No.	131857-25-5
Molecular Formula	C14H19D3ClN3O4S
Molecular Weight	364.88 g/mol
Synonyms	(6R,7R)-7-Amino-3-[(1-Methyl-1-pyrrolidinio-D3)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chloride; 7-ACA-D3 Quaternary Ammonium Salt; Deuterated 7-ACA Derivative; 7-Aminocephalosporanic Acid-D3 Quaternary Salt; 1-Methyl-1-pyrrolidinium-D3 Cephalosporin Intermediate; (6R,7R)-7-Amino-8-oxo-3-[(1-methylpyrrolidin-1-ium-1-yl-D3)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chloride
EINECS	Contact for details

Quality Control

Our 1-[[(6R,7R)-7-Amino-2-Carboxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-3-Yl]Methyl]-1-Methylpyrrolidinium-D3 Chloride is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity, isotopic enrichment, and chiral integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support development and commercial projects requiring compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.