Description

(Sp)-(-)-n-Methyl-n-[(1R,2S)-(2-Hydroxy-1-Methyl-2-Phenyl)Ethyl]Amino-o-Aniysylphenylphosphine is a chiral, enantiomerically pure phosphine ligand of significant importance in asymmetric synthesis. Its core value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of optically active intermediates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of pharmaceutical intermediates.
• Utilized in asymmetric C-C bond-forming reactions, such as cross-couplings and allylic substitutions.
• Critical for the development of enantioselective catalytic processes in academic and industrial R&D.
• Employed in the synthesis of optically pure natural products and complex organic molecules.
• Used as a key component in catalyst systems for fine chemical and agrochemical manufacturing.
• Acts as a stereodirecting agent in organometallic chemistry and catalyst design.

Basic Information

Product Name	(Sp)-(-)-n-Methyl-n-[(1R,2S)-(2-Hydroxy-1-Methyl-2-Phenyl)Ethyl]Amino-o-Aniysylphenylphosphine
CAS No.	131766-47-7
Molecular Formula	C23H26NOP
Molecular Weight	363.44 g/mol
Synonyms	(Sp)-(-)-n-Methyl-n-[(1R,2S)-(2-Hydroxy-1-methyl-2-phenyl)ethyl]amino-o-aniysylphenylphosphine; (Sp)-(-)-Methyl[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino-o-aniysylphenylphosphine; (Sp)-(-)-Methyl[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino-o-anisylphenylphosphine; (Sp)-(-)-Methyl[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino-o-methoxyphenylphenylphosphine; (Sp)-(-)-Methyl[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino-o-anisylphenylphosphine; (Sp)-(-)-Methyl[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino-o-methoxyphenylphenylphosphine; (Sp)-(-)-Methyl[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino-o-anisylphenylphosphine; (Sp)-(-)-Methyl[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino-o-methoxyphenylphenylphosphine
EINECS	Contact for details

Quality Control

Our (Sp)-(-)-n-Methyl-n-[(1R,2S)-(2-Hydroxy-1-Methyl-2-Phenyl)Ethyl]Amino-o-Aniysylphenylphosphine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and enantiomeric excess (ee) specifications are met. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (ee)	≥ 99.0%
Melting Point	Contact for details
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.