Description

(S)-2,2-Dimethyl-1,3-Dioxolane-4-Acetonitrile is a high-value chiral synthon and protected cyanohydrin derivative, essential for the stereoselective synthesis of complex organic molecules. Its primary value lies in its role as a key building block for introducing the (S)-configuration in pharmaceutical intermediates and fine chemicals, ensuring high enantiomeric purity in the final products. This compound is critically needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for producing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor for the synthesis of β-blockers, antiviral agents, and other enantiomerically pure drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or starting material in catalytic asymmetric reactions to construct complex molecular architectures.
• Agrochemical Synthesis: Serves as a building block for creating chiral herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and catalysis research.
• Natural Product Synthesis: Used in the total synthesis of complex natural products where the (S)-configured cyanohydrin moiety is present.

Basic Information

Product Name	(S)-2,2-Dimethyl-1,3-Dioxolane-4-Acetonitrile
CAS No.	131724-43-1
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(S)-(-)-2,2-Dimethyl-1,3-dioxolane-4-acetonitrile; (S)-2,2-Dimethyl-4-cyanomethyl-1,3-dioxolane; (S)-4-(Cyanomethyl)-2,2-dimethyl-1,3-dioxolane; (S)-Acetone cyanohydrin acetonide; (S)-1,2-O-Isopropylidene-D-glyceraldehyde cyanohydrin; (S)-D-Glyceraldehyde Acetone Cyanohydrin; (S)-D-Glyceronitrile Acetonide; L-Glyceraldehyde Acetonide Cyanohydrin
EINECS	Contact for details

Quality Control

Our (S)-2,2-Dimethyl-1,3-Dioxolane-4-Acetonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to confirm identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.