Description

n-Acetylcysteine-6,7-Dihydro-7-Hydroxy-1-Hydroxymethyl-5H-Pyrrolizine is a key pyrrolizidine alkaloid metabolite and a critical reference standard in toxicology and pharmaceutical research. This compound matters for its role in the study of hepatotoxic mechanisms and the development of analytical methods for detecting pyrrolizidine alkaloid exposure in food, herbal products, and biological samples. It is primarily needed by analytical laboratories, pharmaceutical R&D departments, and regulatory agencies focused on product safety and toxicological assessment.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of pyrrolizidine alkaloid metabolites in drug metabolism and pharmacokinetic (DMPK) studies.
• Toxicology Research: Essential for investigating the bioactivation pathways, hepatotoxicity, and genotoxicity associated with pyrrolizidine alkaloids, supporting safety assessments.
• Analytical Method Development: Serves as a critical standard for calibrating equipment and validating methods in HPLC-MS/MS and LC-MS analyses for food and herbal supplement safety testing.
• Biomarker Studies: Employed in the development of assays to detect DNA adducts and protein adducts formed by reactive pyrrolizidine metabolites, useful for exposure monitoring.
• Regulatory Compliance Testing: Used by quality control laboratories to ensure herbal medicines, teas, and food products comply with strict limits on pyrrolizidine alkaloid content.
• Academic Research: A vital tool for universities and research institutes studying the chemistry, metabolism, and toxicological impact of natural toxins.

Basic Information

Item	Detail
Product Name	n-Acetylcysteine-6,7-Dihydro-7-Hydroxy-1-Hydroxymethyl-5H-Pyrrolizine
CAS No.	131711-46-1
Molecular Formula	C12H17NO5S
Molecular Weight	287.33 g/mol
Synonyms	NAC-DHP; 7-Hydroxy-1-hydroxymethyl-6,7-dihydro-5H-pyrrolizine N-acetylcysteine conjugate; N-Acetylcysteine conjugate of DHP; 1-Hydroxymethyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine N-acetylcysteine adduct; Pyrrolizidine alkaloid metabolite (NAC); DHP-NAC; 7,9-Dihydroxy-1-hydroxymethyl-6,7-dihydro-5H-pyrrolizine N-acetylcysteine derivative
EINECS	Contact for details

Quality Control

Our n-Acetylcysteine-6,7-Dihydro-7-Hydroxy-1-Hydroxymethyl-5H-Pyrrolizine is produced and handled under strict quality management systems. Each batch is characterized and tested to ensure high purity and consistency, meeting the rigorous demands of analytical and research applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to confirm identity, purity, and strength.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the container to reach room temperature in a desiccator before opening to minimize exposure to moisture. This material should be handled in accordance with laboratory safety procedures for chemical reagents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 2.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.