Description

(S)-2-(((Benzyloxy)Carbonyl)Amino)-3-(4-Cyanophenyl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a protected amine group. This compound is a critical pharmaceutical intermediate used in the synthesis of complex bioactive molecules, particularly in the development of protease inhibitors and other therapeutic agents. It is essential for research and production in pharmaceutical development, peptide chemistry, and advanced organic synthesis, where precise stereochemistry and functional group compatibility are paramount.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially protease inhibitors and other small-molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a specific phenylalanine derivative with a cyano substituent.
• Medicinal Chemistry Research: Serves as a crucial scaffold in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation: The carboxylic acid and protected amine functionalities allow for selective conjugation to other molecules, proteins, or solid supports.
• Chemical Biology Probes: Utilized in the development of enzyme inhibitors and activity-based probes for studying biological pathways.
• Custom Synthesis: A starting material for the preparation of more complex, tailor-made compounds for specialized research and development projects.

Basic Information

Product Name	(S)-2-(((Benzyloxy)Carbonyl)Amino)-3-(4-Cyanophenyl)Propanoic Acid
CAS No.	131669-07-3
Molecular Formula	C18H16N2O4
Molecular Weight	324.33 g/mol
Synonyms	N-Cbz-(S)-4-Cyanophenylalanine; (S)-2-((((Benzyloxy)carbonyl)amino)-3-(4-cyanophenyl)propanoic acid; (S)-N-Carbobenzoxy-4-cyano-phenylalanine; Z-4-CN-Phe-OH; Cbz-4-Cyano-L-phenylalanine; Nα-Cbz-4-cyano-L-phenylalanine; (S)-2-(Benzyloxycarbonylamino)-3-(4-cyanophenyl)propionic acid; (2S)-2-{[(Benzyloxy)carbonyl]amino}-3-(4-cyanophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our (S)-2-(((Benzyloxy)Carbonyl)Amino)-3-(4-Cyanophenyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.