Description

Major Membrane Immunogen, Treponema Pallidum 15K is a purified, high-molecular-weight protein complex derived from the causative agent of syphilis. This specialized immunogen is critical for the research, development, and production of highly specific diagnostic assays and immunological reagents. It is primarily utilized by biotechnology firms, in-vitro diagnostic (IVD) manufacturers, and advanced research institutions focused on infectious disease diagnostics and vaccine development.

Application

• Diagnostic Assay Development: As a key antigen for the development and calibration of enzyme-linked immunosorbent assays (ELISA), immunoblots, and rapid diagnostic tests (RDTs) for syphilis.
• Antibody Production & Purification: Used as an immunizing agent for generating high-titer, specific polyclonal or monoclonal antibodies in animal models.
• Research Reagent: Serves as a critical research tool for studying Treponema pallidum pathogenicity, host immune response, and antigenic structure in academic and pharmaceutical R&D.
• Quality Control & Reference Standard: Acts as a reference material for lot-to-lot consistency testing and validation of commercial diagnostic kits to ensure accuracy and reliability.
• Vaccine Research: Investigated as a potential component in preclinical studies for syphilis vaccine development.

Basic Information

Product Name	Major Membrane Immunogen, Treponema Pallidum 15K
CAS No.	131595-97-6
Molecular Formula	Contact for details
Molecular Weight	~15 kDa (Complex Protein)
Synonyms	Tp15 Antigen; Treponema pallidum 15 kDa Membrane Protein; Tp15 Immunogen; Syphilis Immunogen 15K; TpN15; 15 kDa Major Membrane Immunogen; Treponemal Membrane Antigen; Diagnostic Grade Tp15
EINECS	Contact for details

Quality Control

Our Major Membrane Immunogen, Treponema Pallidum 15K is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is characterized for purity, specificity, and immunoreactivity using advanced analytical techniques including SDS-PAGE, Western Blot, and ELISA. Certificates of Analysis (COA) detailing purity, protein concentration, endotoxin levels, and performance data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles. Keep container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (Western Blot)	Reacts specifically with anti-T. pallidum antibodies
Purity (SDS-PAGE)	≥ 90% (Single band at ~15 kDa under reducing conditions)
Protein Content (BCA/Bradford)	≥ 1 mg/vial (Contact for exact lot-specific value)
Endotoxin Level (LAL)	< 1.0 EU/mg
Solubility	Soluble in appropriate aqueous buffers (e.g., PBS)
Biological Activity (ELISA)	Demonstrates specific binding in standardized immunoassays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.