Description

Calmodulin (78-148) CAS NO 131588-12-0 is a high-purity, biologically active peptide fragment derived from the central regulatory protein calmodulin. This specific sequence is critical for studying calcium signal transduction mechanisms and protein-protein interactions in biochemical research. It is an essential reagent for pharmaceutical R&D, academic research, and diagnostic assay development. The product is supplied with stringent quality control to ensure batch-to-batch consistency and reliable performance in sensitive applications.

Application

• Biochemical Research: Used as a key reagent in studies of calcium/calmodulin-dependent enzyme regulation and signal transduction pathways.
• Pharmaceutical Development: Serves as a reference standard and tool compound for screening and validating drug candidates targeting calmodulin-mediated processes.
• Diagnostic Assays: Employed in the development of ELISA and other immunoassays for detecting calmodulin or related biomarkers.
• Enzyme Activity Studies: Acts as a specific activator or inhibitor in kinetic assays for enzymes like phosphodiesterase and calcineurin.
• Structural Biology: Utilized in NMR, X-ray crystallography, and other techniques to map protein interaction sites and conformational changes.
• Cell Signaling Probes: Can be labeled (e.g., fluorescently) for use in cellular imaging and localization studies.

Basic Information

Product Name	Calmodulin (78-148)
CAS No.	131588-12-0
Molecular Formula	C332H527N97O100S
Molecular Weight	~7580.5 g/mol
Synonyms	Calmodulin Fragment 78-148; CaM (78-148); Calmodulin Peptide (78-148); CaM Fragment; Calcium-modulated protein fragment; CaMBP; CaM-binding peptide; Ca2+-binding regulatory peptide
EINECS	Contact for details

Quality Control

Our Calmodulin (78-148) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of purity and biological activity. Each batch is characterized by multiple orthogonal methods, including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, sequence verification, and performance data is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Sequence	H-Arg-Gln-Ile-Asn-Ala-Phe...Asp-Phe-Lys-Leu-OH (78-148)
Molecular Weight	7580.5 ± 2.0 Da (Monoisotopic)
Water Content (KF)	≤ 5.0%
Biological Activity	Assay-dependent; COA provided

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.