Description

(E)-2-Hydroxy Doxepin is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant doxepin. This compound is of significant importance for research and development in neuropharmacology and for the synthesis of active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, impurity profiling, and the production of reference standards.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and scale-up of doxepin and related tricyclic antidepressant compounds.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism, efficacy, and safety profile of doxepin.
• Impurity Profiling: Serves as a known impurity standard to ensure the purity and compliance of doxepin API batches with pharmacopeial specifications (e.g., USP, EP).
• Biochemical Research: Utilized in vitro and in vivo studies to investigate the mechanism of action and side effects of tricyclic antidepressants.

Basic Information

Product Name	(E)-2-Hydroxy Doxepin
CAS No.	131523-90-5
Molecular Formula	C19H21NO2
Molecular Weight	295.38 g/mol
Synonyms	(E)-2-Hydroxydoxepin; (E)-Doxepin 2-Hydroxy Metabolite; (E)-2'-Hydroxydoxepin; (E)-N,N-Dimethyl-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-1-propanamine 2-Hydroxy Derivative; 2-Hydroxy-(E)-doxepin; trans-2-Hydroxy Doxepin
EINECS	Contact for details

Quality Control

Our (E)-2-Hydroxy Doxepin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.