Description

Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1S-Trans)- (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. Its unique cyclobutane ring fused with an acetyl and nitrile functional group makes it a valuable building block for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where precise stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis: Utilized as a precursor in catalytic asymmetric reactions to introduce the cyclobutane moiety with high enantiomeric purity.
• Agrochemical Research: Serves as a building block for creating new generations of herbicides and pesticides with enhanced specificity.
• Material Science: Investigated for the synthesis of specialized polymers and liquid crystals where the rigid cyclobutane structure imparts desired physical properties.
• Flavor & Fragrance Chemistry: Potential intermediate for synthesizing complex macrocyclic or musky odorants.
• Academic & Process Chemistry: Used in methodological studies and scale-up process optimization for complex organic transformations.

Basic Information

Item	Details
Product Name	Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1S-Trans)- (9Ci)
CAS No.	131488-86-3
Molecular Formula	C10H15NO
Molecular Weight	165.23 g/mol
Synonyms	(1S,3R)-3-Acetyl-2,2-dimethylcyclobutaneacetonitrile; (1S-trans)-3-Acetyl-2,2-dimethylcyclobutanecetonitrile; trans-3-Acetyl-2,2-dimethylcyclobutaneacetonitrile; 2,2-Dimethyl-3-acetylcyclobutaneacetonitrile; 3-Acetyl-2,2-dimethylcyclobutaneacetonitrile; Cyclobutanecetonitrile, 3-acetyl-2,2-dimethyl-, (1S-trans)-; (1S,3R)-3-Acetyl-2,2-dimethylcyclobutanecetonitrile
EINECS	Contact for details

Quality Control

Our production of Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1S-Trans)- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chiral purity, chemical purity (by HPLC/GC), and identity confirmation. We are committed to meeting the exacting requirements of GMP and ISO-guided environments for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.