Description

1-Myristoyl-2-(6-(4,4-Dimethyloxazolidine-n-Oxyl)Myristoyl)-3-Phosphatidylcholine is a specialized, spin-labeled phospholipid derivative, uniquely engineered for advanced research applications. Its core value lies in the incorporation of a stable nitroxide radical (TEMPO) into the *sn*-2 fatty acyl chain, making it an indispensable tool for probing membrane dynamics and structure. This compound is critically needed by researchers in biophysics, structural biology, and pharmaceutical sciences for applications such as electron paramagnetic resonance (EPR) spectroscopy and membrane modeling.

Application

• Membrane Biophysics Research: As a spin-label probe for Electron Paramagnetic Resonance (EPR) spectroscopy to study lipid bilayer fluidity, phase transitions, and protein-lipid interactions.
• Structural Biology: Used in site-directed spin labeling (SDSL) experiments to investigate the structure and conformational changes of membrane proteins.
• Liposome & Model Membrane Formation: A key component for creating stable, characterized liposomes and planar bilayers for drug delivery and permeability studies.
• Antioxidant Activity Studies: The nitroxide moiety allows for the investigation of radical scavenging and oxidative processes within lipid environments.
• Magnetic Resonance Imaging (MRI) Contrast Agent Development: Serves as a building block for developing novel, targeted contrast agents based on stable radicals.
• Pharmaceutical R&D: Used in pre-formulation studies to understand drug partitioning and behavior in biological membranes.

Basic Information

Product Name	1-Myristoyl-2-(6-(4,4-Dimethyloxazolidine-n-Oxyl)Myristoyl)-3-Phosphatidylcholine
CAS No.	131483-46-0
Molecular Formula	C₄₃H₈₃N₂O₉P
Molecular Weight	827.10 g/mol
Synonyms	1-Myristoyl-2-(6-(4,4-dimethyloxazolidine-N-oxyl)myristoyl)-sn-glycero-3-phosphocholine; 14:0-6-TEMPO PC; TEMPO-PC; Spin-labeled phosphatidylcholine; 1-Myristoyl-2-(6-TEMPO-myristoyl)-sn-glycero-3-phosphocholine; Nitroxide-labeled PC; 1,2-Dimyristoyl-sn-glycero-3-phospho(TEMPO)choline; EPR Probe Lipid
EINECS	Contact for details

Quality Control

Every batch of our spin-labeled phospholipids is produced and analyzed under strict quality control protocols to ensure high purity and consistent performance for sensitive research applications. Standard analytical techniques including HPLC, NMR, and EPR spectroscopy are employed for characterization. A comprehensive Certificate of Analysis (COA) detailing purity, radical concentration, and identification is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation of the nitroxide radical. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (EPR)	≥ 95% active radical
Solubility	Soluble in chloroform, ethanol; forms liposomes in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.