Description

4-Trifluoromethyl-Benzamidine is a high-purity organic building block featuring a benzamidine core substituted with a trifluoromethyl group. This compound is valued for its role as a key synthetic intermediate in the development of advanced pharmaceuticals and agrochemicals, where the CF3 group is crucial for modulating biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that benefit from the properties of the trifluoromethyl group.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing activity-based probes and inhibitors to study enzyme function and protein-protein interactions.
• Material Science Research: Employed as a precursor for developing specialty polymers and advanced organic materials with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	4-Trifluoromethyl-Benzamidine
CAS No.	131472-28-1
Molecular Formula	C8H7F3N2
Molecular Weight	188.15 g/mol
Synonyms	4-(Trifluoromethyl)benzamidine; p-Trifluoromethylbenzamidine; Benzenecarboximidamide, 4-(trifluoromethyl)-; α,α,α-Trifluoro-p-toluamidine; 4-CF3-Benzamidine; 4-Trifluoromethylbenzenecarboximidamide
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-Benzamidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.