Description

Connexin 45 CAS NO 131461-62-6 is a synthetic peptide that functions as a specific inhibitor of the Connexin 45 (Cx45) gap junction protein. This compound is a critical research tool for investigating intercellular communication, electrical coupling, and signaling pathways in various biological systems. It is primarily utilized by researchers and scientists in the fields of cardiology, neuroscience, and oncology for fundamental research and drug discovery applications.

Application

• Cardiac Electrophysiology Research: Used to study the role of Cx45 in cardiac conduction, arrhythmias, and the development of the cardiac conduction system.
• Neuroscience Studies: Applied in research on neuronal synchronization, synaptic plasticity, and the function of electrical synapses in the central nervous system.
• Cancer Research: Investigates the involvement of gap junction communication in tumor progression, metastasis, and the tumor microenvironment.
• Developmental Biology: Aids in understanding tissue patterning and organogenesis where Cx45-mediated communication is crucial.
• Pharmacological Screening: Serves as a reference compound or tool in high-throughput assays to identify novel modulators of gap junction activity.
• Cell Culture & In Vitro Models: Used to selectively block Cx45 channels in primary cell cultures or engineered tissue models to dissect specific signaling pathways.

Basic Information

Product Name	Connexin 45
CAS No.	131461-62-6
Molecular Formula	C186H294N56O58S
Molecular Weight	~4250.8 g/mol
Synonyms	Gap Junction α-5 Protein Inhibitor; Cx45 Inhibitory Peptide; Connexin-45 (130-138); Cx45 Gap Junction Blocker; GJA7 Inhibitor; Peptide Inhibitor of Connexin 45; Cx45 Blocking Peptide; Antiarrhythmic Peptide Analog
EINECS	Contact for details

Quality Control

Our Connexin 45 peptide is manufactured under strict conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, sequence, and analytical data are provided to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Sequence	VDCFLSRPTEKT
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.