Description

n-Methylleukotriene C4 is a synthetic analog of the potent lipid mediator leukotriene C4, designed for advanced biochemical and pharmacological research. This compound is critical for studying the cysteinyl leukotriene pathway, which plays a key role in inflammatory and allergic responses. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for target validation, assay development, and as a reference standard.

Application

• Biochemical Research: Used as a high-purity reference standard in the study of leukotriene receptors (CysLT1 and CysLT2) and their signaling pathways.
• Drug Discovery & Development: Serves as a critical tool for screening and evaluating potential antagonists for inflammatory diseases such as asthma, allergic rhinitis, and anaphylaxis.
• In Vitro & In Vivo Studies: Employed in cellular assays and animal models to investigate the physiological and pathophysiological roles of cysteinyl leukotrienes.
• Analytical Method Development: Used to calibrate and validate analytical methods, including HPLC and LC-MS/MS, for the quantification of leukotrienes in complex matrices.
• Enzyme Interaction Studies: Applied in research on enzymes involved in the synthesis and metabolism of leukotrienes, such as glutathione S-transferases.

Basic Information

Product Name	n-Methylleukotriene C4
CAS No.	131391-65-6
Molecular Formula	C24H39N3O7S
Molecular Weight	513.65 g/mol
Synonyms	N-Methyl-LTC4; Leukotriene C4, N-methyl-; (5S,6R)-N-Methyl-7-[(1R,2E,4E,6Z,9Z)-1-[(1S)-1-hydroxy-4-(2-hydroxyethylthio)-1-methylbutoxy]-2,4,6,9-heptadecatetraen-1-yl]-5-hydroxy-4-oxo-2,8-dioxa-4-azatetracos-14Z-enoic Acid; Methyl LTC4; N-Methylcysteinylleukotriene C4
EINECS	Contact for details

Quality Control

Our n-Methylleukotriene C4 is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.