Description

Farnesyltransferase CAS NO 131384-38-8 is a critical enzyme involved in the post-translational modification of proteins, specifically catalyzing the transfer of a farnesyl group to cysteine residues. This process, known as protein farnesylation, is essential for the proper localization and function of key signaling proteins, including Ras and other GTPases. As a result, this enzyme is a primary target for research in oncology, neurodegenerative diseases, and parasitology, making it indispensable for pharmaceutical R&D, academic research institutions, and biotechnology companies developing targeted therapeutic inhibitors.

Application

• Drug Discovery & Development: Primary target for the development of farnesyltransferase inhibitors (FTIs) as potential anticancer and anti-parasitic therapeutics.
• Biochemical Research: Used as a key reagent in enzymatic assays to study protein prenylation pathways, signal transduction, and cell cycle regulation.
• Oncology Research: Essential for investigating the role of Ras oncogene activation and validating FTIs in preclinical cancer models.
• Neurodegenerative Disease Studies: Employed in research focused on the farnesylation of proteins implicated in conditions like Progeria and Huntington's disease.
• Parasitology: Investigated as a target for novel treatments against parasitic infections like malaria, where the enzyme is vital for parasite survival.
• Diagnostic Kit Development: Serves as a core component in the development of high-throughput screening kits and diagnostic assays for research purposes.

Basic Information

Product Name	Farnesyltransferase
CAS No.	131384-38-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Protein farnesyltransferase; CAAX farnesyltransferase; Farnesyl protein transferase; FTase; Ras protein farnesyltransferase; Prenyltransferase; EC 2.5.1.58; Farnesyltransferase inhibitor target enzyme
EINECS	Contact for details

Quality Control

Our Farnesyltransferase is produced and handled under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, specific activity, and functional integrity. Quality parameters are verified through methods including SDS-PAGE, activity assays, and protein concentration analysis. A comprehensive Certificate of Analysis (COA) detailing purity, activity (units/mg), and storage buffer composition is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	Clear to slightly opalescent solution
Identification (Activity)	Functional activity confirmed by standard enzymatic assay
Purity (SDS-PAGE)	≥ 90%
Specific Activity	Contact for details
Protein Concentration	Contact for details
Buffer Composition	Tris-HCl, Glycerol, DTT, NaCl
Endotoxin Level	< 1.0 EU/µg (for research-grade material)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.