Description

Ethyl-2,2-Difluoro-2-(4-Methylphenyl)Acetate is a high-purity fluorinated aromatic ester building block, valued for its role in introducing the difluoromethylenecarboxylate moiety into complex molecules. This compound is essential for advanced synthetic chemistry, particularly in the development of pharmaceuticals and agrochemicals where fluorine substitution is critical for modulating biological activity and metabolic stability. It serves as a key intermediate for researchers and manufacturers in fine chemical, pharmaceutical R&D, and agrochemical synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring difluorinated aromatic structures to enhance potency and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental stability.
• Material Science Research: Employed in the development of novel fluorinated polymers and specialty materials with unique surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: Acts as a precursor in the synthesis of fluorinated organic compounds for electronic displays and optoelectronic devices.
• Organic Synthesis Reagent: Serves as a versatile reagent in academic and industrial laboratories for constructing complex molecules via reactions like Horner-Wadsworth-Emmons or other carbonyl olefination pathways.

Basic Information

Product Name	Ethyl-2,2-Difluoro-2-(4-Methylphenyl)Acetate
CAS No.	131323-06-3
Molecular Formula	C11H12F2O2
Molecular Weight	214.21 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(p-tolyl)acetate; 2,2-Difluoro-2-(4-methylphenyl)acetic Acid Ethyl Ester; Ethyl α,α-Difluoro-p-toluate; Ethyl (4-Methylphenyl)difluoroacetate; p-Tolyl(difluoro)acetic Acid Ethyl Ester; Acetic acid, 2,2-difluoro-2-(4-methylphenyl)-, ethyl ester; DFMPA-Et
EINECS	Contact for details

Quality Control

Our Ethyl-2,2-Difluoro-2-(4-Methylphenyl)Acetate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.