Description

Technetium Tc 99M Cyclobutylpropyleneamine Oxime is a diagnostic radiopharmaceutical agent used in nuclear medicine imaging. Its primary value lies in its ability to cross the intact blood-brain barrier, allowing for the assessment of regional cerebral blood flow. This makes it a critical tool for neurologists and radiologists in clinical and research settings. It is essential for single-photon emission computed tomography (SPECT) to evaluate conditions such as stroke, dementia, and epilepsy.

Application

• Neurological SPECT Imaging: Primary application for the evaluation of regional cerebral perfusion.
• Cerebrovascular Disease Assessment: Used in the diagnosis and management of stroke, transient ischemic attack (TIA), and related disorders.
• Dementia Evaluation: Aids in differentiating between Alzheimer's disease, vascular dementia, and other neurodegenerative conditions.
• Epilepsy Focus Localization: Assists in identifying the epileptogenic focus in patients with partial seizures.
• Brain Trauma Studies: Used to assess cerebral blood flow changes following head injury.
• Psychiatric Research: Employed in research studies to investigate cerebral blood flow patterns in various psychiatric disorders.

Basic Information

Item	Details
Product Name	Technetium Tc 99M Cyclobutylpropyleneamine Oxime
CAS No.	131315-61-2
Molecular Formula	C14H26N2O2 • 99mTc
Molecular Weight	Contact for details
Synonyms	Technetium Tc 99m Exametazime; 99mTc-HMPAO; Ceretec™; Exametazime; Hexamethylpropyleneamine Oxime (HMPAO) labeled with Technetium-99m; Neurolite®; Propyleneamine Oxime, N,N'-1,2-ethylenediylbis[N-(2-methyl-2-propanyl)-, complex with technetium-99m
EINECS	Contact for details

Quality Control

As a pharmaceutical active ingredient for diagnostic use, this product is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for radiochemical purity, pH, sterility, and apyrogenicity as required for injectable radiopharmaceuticals. Certificates of Analysis (COA) detailing all release tests, including chromatography results, are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at the temperature recommended for the specific kit formulation, typically between 2°C and 8°C (refrigerated) prior to reconstitution. The prepared injection must be used within the specified time window post-reconstitution due to the radioactive decay of Technetium-99m. Follow all radiation safety protocols for handling and storage.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC/Radio-TLC)	Conforms to standard
Radiochemical Purity (HPLC)	≥ 90.0%
pH	6.5 - 7.5
Sterility Test	Sterile
Bacterial Endotoxins	< 175 EU/Vial
Radioactivity Concentration	As per COA at time of calibration

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.