Description

Fk Binding Protein CAS NO 131144-19-9 is a high-purity, biologically active protein used in advanced biochemical research and pharmaceutical development. This compound is critical for studying intracellular signaling pathways, protein-protein interactions, and as a key reagent in immunophilin-related assays. It is primarily utilized by research institutions, biotechnology companies, and pharmaceutical developers focused on neurobiology, immunology, and drug discovery. The product is supplied under stringent quality controls to ensure batch-to-batch consistency and optimal performance in sensitive applications.

Application

• Biochemical Research: Essential tool for studying FK506 (tacrolimus) and rapamycin (sirolimus) binding mechanisms and their effects on T-cell activation and immunosuppression.
• Drug Discovery & Development: Used as a target protein in high-throughput screening (HTS) assays to identify novel immunomodulators and neuroprotective agents.
• Enzyme Activity Studies: Serves as a co-chaperone in peptidyl-prolyl cis-trans isomerase (PPIase) activity assays to investigate protein folding.
• Diagnostic Reagent Production: A key component in the development of diagnostic kits and reagents for research into autoimmune and neurological disorders.
• Cell Signaling Pathway Analysis: Employed in pull-down assays, co-immunoprecipitation, and other techniques to map signal transduction networks involving calcineurin inhibition.
• Reference Standard: Used as a purified standard in quantitative analysis, method validation, and quality control within biopharmaceutical manufacturing.

Basic Information

Product Name	Fk Binding Protein CAS NO 131144-19-9
CAS No.	131144-19-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FKBP; FKBP12; FK506 Binding Protein; FKBP-12; Immunophilin FKBP12; Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A; Rotamase; Tacrolimus Binding Protein; 12 kDa FK506-binding protein; FKBP1A
EINECS	Contact for details

Quality Control

Our Fk Binding Protein is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC, identity confirmation, and bioactivity assays, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, specific activity, and endotoxin levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.