Description

Silteplase is a recombinant tissue-type plasminogen activator (rt-PA) variant, a potent thrombolytic agent engineered for enhanced fibrin specificity and a longer plasma half-life. This engineered protein is critical for the effective and rapid dissolution of pathological blood clots, offering a significant therapeutic advantage in acute vascular occlusions. It is primarily required by pharmaceutical manufacturers and research institutions developing next-generation treatments for acute ischemic stroke, myocardial infarction, and other thromboembolic disorders.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of advanced thrombolytic drugs for emergency medicine.
• Acute Ischemic Stroke Therapy: Used in the development of medications aimed at restoring cerebral blood flow by breaking down occlusive clots.
• Acute Myocardial Infarction Treatment: Employed in cardiac care formulations to lyse coronary artery thrombi and limit heart muscle damage.
• Research & Development: Serves as a key reference standard and investigational material in cardiovascular and cerebrovascular disease research.
• Biotechnological Studies: Utilized in studies focusing on protein engineering, fibrinolytic mechanisms, and pharmacokinetics of therapeutic proteins.

Basic Information

Product Name	Silteplase
CAS No.	131081-40-8
Molecular Formula	C2560H3924N746O781S40
Molecular Weight	Approx. 59 kDa
Synonyms	BM 06.022; Recombinant Tissue-Type Plasminogen Activator Mutant; r-PA Variant; Plasminogen Activator, Tissue-Type, Recombinant Mutant; E6010; Silteplasa; rt-PA Mutant
EINECS	Contact for details

Quality Control

Our Silteplase is manufactured under strict quality systems. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and safety, meeting the stringent requirements for biopharmaceutical actives. Certificates of Analysis (COA) detailing specifications such as biological activity, purity by HPLC, and endotoxin levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize condensation. For long-term storage, maintain under recommended frozen conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/Peptide Map)	Conforms to reference standard
Purity (SDS-PAGE & HPLC)	≥ 98.0%
Biological Activity (Clot Lysis)	≥ 500,000 IU/mg
Protein Content	≥ 95.0% (by UV)
Endotoxins	< 10 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.