Description

n-(2-Mercapto-2-Methylpropionyl)-D-Cysteine is a specialized chiral cysteine derivative featuring a unique thioester and thiol functional group combination. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its role as a key intermediate in the synthesis of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including enzyme inhibitors and targeted drug conjugates. Its specific stereochemistry and reactive groups make it a valuable building block for creating compounds with precise biological activity.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor research.
• Bioconjugation Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other targeted therapies due to its reactive thiol group for site-specific linkage.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, especially for cysteine protease enzymes, aiding in mechanistic and kinetic investigations.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide synthesis to introduce modified cysteine residues, altering peptide stability and bioactivity.
• Precursor for Chelating Agents: Acts as a precursor for synthesizing specialized chelating ligands used in metal catalysis or diagnostic imaging agents.

Basic Information

Product Name	n-(2-Mercapto-2-Methylpropionyl)-D-Cysteine
CAS No.	130999-94-9
Molecular Formula	C7H13NO3S2
Molecular Weight	223.31 g/mol
Synonyms	D-Cysteine, N-(2-mercapto-2-methyl-1-oxopropyl)-; (R)-2-((2-Mercapto-2-methylpropanoyl)thio)-3-aminopropanoic acid; 2-Methyl-2-sulfanylpropanoyl-D-cysteine; D-Cys(MMP); MMP-D-Cysteine; N-(2-Mercaptoisobutyryl)-D-cysteine; (R)-2-Amino-3-((2-mercapto-2-methylpropanoyl)thio)propanoic acid
EINECS	Contact for details

Quality Control

Our n-(2-Mercapto-2-Methylpropionyl)-D-Cysteine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and moisture absorption. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.