Description

(1-Adamantaneacetyl-D-Arg0,Hyp3,β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin is a highly specialized, synthetic bradykinin analog designed for advanced research and development. This compound is engineered for superior stability and receptor selectivity, making it a critical tool for investigating cardiovascular, inflammatory, and pain pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on novel therapeutic discovery.

Application

• Pharmacological Research: A key tool for studying the bradykinin B2 receptor (B2R) and its role in vasodilation, inflammation, and pain signaling.
• Drug Discovery Programs: Used as a reference standard or lead compound in the development of new analgesics, anti-inflammatory agents, and cardiovascular drugs.
• Biochemical Assay Development: Serves as a high-affinity ligand in receptor binding assays, functional cell-based assays, and signal transduction studies.
• Structure-Activity Relationship (SAR) Studies: The unique adamantane and thienylalanine modifications make it ideal for probing receptor-ligand interactions and optimizing peptide stability.
• Academic & Clinical Research: Supports fundamental research into conditions like sepsis, angioedema, chronic pain, and hypertension.

Basic Information

Product Name	(1-Adamantaneacetyl-D-Arg0,Hyp3,β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin
CAS No.	130942-96-0
Molecular Formula	C71H98N18O13S
Molecular Weight	1443.7 g/mol
Synonyms	Bradykinin B2 Receptor Agonist; [D-Arg0, Hyp3, β-(2-Thienyl)-Ala5,8, D-Phe7]-Bradykinin, 1-Adamantaneacetyl-; Adamantaneacetyl-Bradykinin Analog; B-9972; HOE-140 derivative; ThiAla5,8-Bradykinin analog; Synthetic Bradykinin Peptide; B2R Selective Agonist
EINECS	Contact for details

Quality Control

Every batch of our (1-Adamantaneacetyl-D-Arg0,Hyp3,β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin is manufactured under strict quality systems and undergoes comprehensive analytical characterization. We ensure compliance with high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) providing data on purity, identity, and impurities is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in DMSO, acetic acid; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.