Description

Neurotrophin-3, Human is a purified recombinant protein that plays a critical role in the development, maintenance, and function of neurons in the peripheral and central nervous systems. This high-purity growth factor is essential for research and development in neuroscience, offering a reliable tool for studying neuronal survival, differentiation, and synaptic plasticity. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in neurobiological research and therapeutic discovery programs.

Application

• Neuroscience Research: Fundamental studies on neuronal development, survival, and axon guidance.
• Cell Culture & Differentiation: A key component in media for the maintenance and directed differentiation of neural stem cells and primary neurons.
• Drug Discovery Screening: Used in high-throughput assays to identify novel compounds that modulate neurotrophin signaling pathways for potential neurodegenerative disease therapies.
• Biomanufacturing Process Development: Serves as a critical quality attribute standard in the production of cell-based therapies and other biologics targeting the nervous system.
• Diagnostic Development: Employed as a calibrator or reference material in immunoassays designed to measure neurotrophin levels in clinical samples.

Basic Information

Product Name	Neurotrophin-3, Human
CAS No.	130939-66-1
Molecular Formula	Contact for details
Molecular Weight	Approx. 13.6 kDa (monomer)
Synonyms	NT-3; NT3; Neurotrophin-3; HDNF; Human Neurotrophin-3; Recombinant Human Neurotrophin-3; rhNT-3; Nerve Growth Factor 2; NGF-2; Hippocampal Derived Neurotrophic Factor
EINECS	Contact for details

Quality Control

Our Neurotrophin-3, Human is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is rigorously tested for identity, purity, potency, and endotoxin levels. Comprehensive Certificates of Analysis (COA) detailing specifications such as purity by SDS-PAGE and HPLC, biological activity in cell-based assays, and endotoxin content are provided to guarantee reproducible and reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band corresponding to ~13.6 kDa
Purity (HPLC)	≥ 95%
Biological Activity	Determined by cell proliferation assay
Endotoxin	< 1.0 EU/μg
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.