Description

(2R,4S,5R)-(+)-2,5-Diphenyl-3,4-Dimethyl-1,3,2-Oxazaphospholidine-2-Borane is a high-purity, chiral organophosphorus compound, specifically a borane-protected oxazaphospholidine, widely recognized for its role as a versatile chiral auxiliary and ligand in asymmetric synthesis. Its primary value lies in enabling highly enantioselective transformations, crucial for producing optically active intermediates in pharmaceutical and fine chemical research. This product is essential for R&D chemists and process development scientists working in asymmetric catalysis, medicinal chemistry, and the synthesis of chiral active pharmaceutical ingredients (APIs).

Application

• Chiral Ligand in Asymmetric Catalysis: Employed in enantioselective hydrogenation, hydroboration, and hydrosilylation reactions.
• Chiral Auxiliary in Organic Synthesis: Used for the diastereoselective formation of carbon-phosphorus and carbon-heteroatom bonds.
• Pharmaceutical Intermediate Synthesis: Key building block for constructing complex, optically pure molecules in drug discovery and development.
• Asymmetric Induction Agent: Facilitates the creation of stereogenic centers with high enantiomeric excess (ee) in target molecules.
• Research & Development: A critical tool for academic and industrial research focused on new methodologies in stereoselective synthesis.
• Fine Chemical Production: Used in the pilot and commercial-scale manufacture of specialty chemicals requiring specific chirality.

Basic Information

Product Name	(2R,4S,5R)-(+)-2,5-Diphenyl-3,4-Dimethyl-1,3,2-Oxazaphospholidine-2-Borane
CAS No.	130666-29-4
Molecular Formula	C17H21BNOP
Molecular Weight	297.14 g/mol
Synonyms	(+)-2,5-Diphenyl-3,4-dimethyl-1,3,2-oxazaphospholidine-2-borane; (2R,4S,5R)-2,5-Diphenyl-3,4-dimethyl-1,3,2-oxazaphospholidine borane; (R,R,S)-2,5-Diphenyl-3,4-dimethyl-1,3,2-oxazaphospholidine-2-borane; Chiral oxazaphospholidine-borane complex; DIPAMP analogue borane adduct; Borane-2,5-diphenyl-3,4-dimethyl-1,3,2-oxazaphospholidine complex; (2R,4S,5R)-DIPAMP-Borane
EINECS	Contact for details

Quality Control

Every batch of our (2R,4S,5R)-(+)-2,5-Diphenyl-3,4-Dimethyl-1,3,2-Oxazaphospholidine-2-Borane is produced and tested under strict quality management protocols to ensure high chemical purity and chiral integrity. Our products undergo rigorous quality testing, including chiral HPLC analysis, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Keep the container tightly sealed to prevent exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Specific Rotation [α]	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.