Description

Nifekalant Hydrochloride is a class III antiarrhythmic agent, specifically a rapid delayed rectifier potassium current (IKr) blocker. This compound is critical for the management of life-threatening ventricular arrhythmias, such as ventricular tachycardia and fibrillation, where other treatments have failed. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in cardiovascular drug development and production.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of injectable antiarrhythmic medications.
• Cardiovascular Research as a reference standard for studying IKr channel pharmacology and cardiac electrophysiology.
• Pharmacological Studies for investigating mechanisms of action and efficacy in models of ventricular arrhythmias.
• Pharmaceutical Development for creating generic or novel drug delivery systems for emergency cardiac care.
• Quality Control Laboratories for use as an analytical reference standard in HPLC and other assay methods.

Basic Information

Product Name	Nifekalant Hydrochloride
CAS No.	130656-51-8
Molecular Formula	C19H27N5O2 • HCl
Molecular Weight	409.91 g/mol
Synonyms	Nifekalant HCl; MS-551; 6-[2-(Diethylamino)ethyl]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride; 1,3-Dimethyl-6-[2-(diethylamino)ethyl]uracil hydrochloride; UNII-1J984QJ3VK; MS551; Nifekalant Monohydrochloride
EINECS	Contact for details

Quality Control

Our Nifekalant Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency meet stringent standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.