Description

Nifekalant CAS NO 130636-43-0 is a potent and selective class III antiarrhythmic agent, functioning as a rapid delayed rectifier potassium current (IKr) blocker. This compound is critical for the research and development of advanced cardiac therapeutics, particularly for the acute treatment of life-threatening ventricular arrhythmias. It is an essential raw material and reference standard for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on cardiovascular drug discovery and quality control.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key active component in the formulation of injectable antiarrhythmic medications.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of drug products and raw materials via HPLC, LC-MS, or other chromatographic techniques.
• Biochemical Research: A vital tool for in vitro and ex vivo studies investigating cardiac electrophysiology, ion channel function, and mechanisms of arrhythmia.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies during the drug development pipeline.
• Chemical Synthesis Intermediate: Acts as a building block or precursor for the synthesis of novel analogs or derivatives in medicinal chemistry programs.

Basic Information

Product Name	Nifekalant
CAS No.	130636-43-0
Molecular Formula	C19H27N3O2
Molecular Weight	329.44 g/mol
Synonyms	MS-551; Nifekalant hydrochloride; SJL-01; (R)-N-[1-[2-(6-Methyl-2-pyridyl)ethyl]-4-piperidyl]-N-phenylurea; 1-[[(2R)-1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]-3-phenylurea; UNII-0V4P7JOF6T
EINECS	Contact for details

Quality Control

Our Nifekalant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, residual solvents, and specific tests. We support compliance with cGMP and ICH guidelines for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.