Description

(R)-2-(tert-Butoxycarbonylamino)-2-((1R,4R)-4-Hydroxycyclohexyl)Acetic Acid is a high-purity, chiral building block of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting complex diseases. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of peptide mimetics, enzyme inhibitors, and other sophisticated therapeutic agents where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel Active Pharmaceutical Ingredients (APIs).
• Peptidomimetic Synthesis: Used to incorporate constrained, stereochemically defined cyclohexylglycine analogs into peptide backbones to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core building block for inhibitors targeting various proteases, such as renin, HIV protease, and thrombin.
• Asymmetric Synthesis: Employed in medicinal chemistry for the asymmetric construction of complex molecules with multiple stereocenters.
• Chemical Biology Research: Utilized as a tool compound or labeled precursor in studying enzyme mechanisms and protein-ligand interactions.
• Process Chemistry & Scale-Up: Suitable for development from milligram to kilogram scale under current Good Manufacturing Practice (cGMP) guidelines for clinical trial material production.

Basic Information

Product Name	(R)-2-(tert-Butoxycarbonylamino)-2-((1R,4R)-4-Hydroxycyclohexyl)Acetic Acid
CAS No.	130624-89-4
Molecular Formula	C₁₃H₂₃NO₅
Molecular Weight	273.33 g/mol
Synonyms	Boc-(R)-Cyclohexylglycine-OH (4-hydroxy); (1R,4R)-4-[(R)-2-[(tert-Butoxycarbonyl)amino]-2-carboxyethyl]cyclohexanol; (R)-2-((1R,4R)-4-Hydroxycyclohexyl)-2-((tert-butoxycarbonyl)amino)acetic acid; N-Boc-trans-4-hydroxy-D-cyclohexylglycine; N-(tert-Butoxycarbonyl)-trans-4-hydroxy-D-cyclohexylglycine; Boc-trans-4-Hydroxy-D-Chg-OH; (R)-2-(Boc-amino)-2-((1R,4R)-4-hydroxycyclohexyl)acetic acid
EINECS	Contact for details

Quality Control

Our (R)-2-(tert-Butoxycarbonylamino)-2-((1R,4R)-4-Hydroxycyclohexyl)Acetic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for pharmaceutical research. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch. Production can be aligned with cGMP standards for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.