Description

L-Proline, 1-(1-Chloroethyl)-, (R)- (9Ci) is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block for the development of novel pharmaceuticals and bioactive molecules, offering a unique proline scaffold with a reactive chloroethyl substituent. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly protease inhibitors and other biologically active compounds.
• Asymmetric Synthesis: Used as a precursor or catalyst component in stereoselective reactions to construct molecules with defined three-dimensional architecture.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the design of novel pharmacophores due to its constrained proline ring system.
• Peptidomimetics Development: Serves as a modified amino acid residue for creating peptide analogs with enhanced stability, bioavailability, or receptor selectivity.
• Agrochemical Synthesis: A potential intermediate in the production of advanced, chiral crop protection agents.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new reaction pathways.

Basic Information

Product Name	L-Proline, 1-(1-Chloroethyl)-, (R)- (9Ci)
CAS No.	130603-14-4
Molecular Formula	C7H12ClNO2
Molecular Weight	177.63 g/mol
Synonyms	(R)-1-(1-Chloroethyl)-L-proline; (2R)-1-(1-Chloroethyl)pyrrolidine-2-carboxylic Acid; L-Proline, 1-(1-chloroethyl)-, (R)-; 1-(1-Chloroethyl)-(R)-proline; (R)-1-(α-Chloroethyl)proline; 130603-14-4; Proline derivative, chloroethyl-
EINECS	Contact for details

Quality Control

Our L-Proline, 1-(1-Chloroethyl)-, (R)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing chiral purity, assay, and impurity profiles are provided and available upon request. We support development and scale-up with reliable, high-quality material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.