Description

Fmoc-Achpa CAS NO 130597-31-8 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for introducing the constrained (R)-1-amino-2-cyclohexylpropanoic acid (Achpa) moiety into peptide chains under Fmoc solid-phase peptide synthesis (SPPS) protocols. It is primarily utilized by pharmaceutical researchers and process chemists in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds. The product is offered with stringent quality control to ensure batch-to-batch consistency and optimal performance in automated synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc-based synthesis of complex peptides incorporating the Achpa scaffold.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs targeting GPCRs, enzymes, and other biological targets.
• Peptidomimetic Design: Enables the creation of conformationally constrained peptide analogs with enhanced metabolic stability and bioavailability.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to identify new lead compounds.
• Bioconjugation: Can be used to introduce specific functional handles into peptides for labeling or conjugation purposes.
• Academic Research: Employed in university and institutional labs for studying peptide structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-Achpa
CAS No.	130597-31-8
Molecular Formula	C₂₅H₂₉NO₄
Molecular Weight	407.50 g/mol
Synonyms	Fmoc-(R)-1-Amino-2-cyclohexylpropanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-cyclohexyl-D-alanine; Fmoc-D-3-cyclohexylalanine; Fmoc-3-Chx-D-Ala-OH; Fmoc-D-Cyh-OH; N-Fmoc-3-cyclohexyl-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Achpa is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive peptide synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to support regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage (over 12 months), consider storage at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.