Description

Il-1β (208-240) (Human) is a defined synthetic peptide fragment corresponding to amino acids 208-240 of the human Interleukin-1 Beta protein. This high-purity reference standard is critical for biochemical research, enabling precise study of protein-protein interactions and signaling pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on immunology, inflammation, and cytokine biology. CAS No. 130587-39-2.

Application

• Biochemical Research: Used as a reference standard in the study of IL-1β structure, function, and receptor binding mechanisms.
• Immunoassay Development: Serves as a critical antigen for the development and calibration of ELISA and other immunoassays targeting specific epitopes of IL-1β.
• Antibody Production & Validation: Acts as an immunogen for generating monoclonal or polyclonal antibodies, and for subsequent antibody specificity testing.
• Inflammation & Cytokine Studies: A key tool for investigating the role of specific IL-1β domains in inflammatory cascades and cellular signaling.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) assays to identify potential therapeutic compounds that modulate IL-1β activity.
• Quality Control: Used as a system suitability standard in the quality control of related biopharmaceutical products and diagnostic kits.

Basic Information

Product Name	Il-1β (208-240) (Human)
CAS No.	130587-39-2
Molecular Formula	C165H263N45O51S
Molecular Weight	3759.2 g/mol (approximate)
Synonyms	Interleukin-1 Beta (208-240) (human); IL-1β (208-240); IL1B (208-240); hIL-1β (208-240); Recombinant Human IL-1β Peptide Fragment (208-240); Amino acids 208-240 of Interleukin-1 Beta; IL1F2 (208-240)
EINECS	Contact for details

Quality Control

Every batch of Il-1β (208-240) (Human) is manufactured and analyzed under stringent conditions to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including multiple orthogonal analytical methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (by MS), and peptide content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. This product is hygroscopic (moisture-sensitive). Solutions should be prepared in appropriate buffers and used immediately or aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Sequence	H-Lys-Val-Thr-Phe-Gln-Glu-Gly-Ser-Asn-Asn-Leu-Val-Leu-Arg-Ala-Asn-Gln-Leu-Ser-Ser-Glu-Phe-Pro-Pro-Val-Leu-Glu-Glu-Val-Lys-OH
Molecular Weight	3759.2 ± 1.0 Da
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.