Description

Substance P, Bpa(8)- CAS NO 130409-05-1 is a specialized synthetic peptide analog of the neuropeptide Substance P, modified with biphenylalanine (Bpa) residues for enhanced stability and specific binding properties. This compound is critical for advanced research in neurobiology and pharmacology, particularly in studies involving the neurokinin-1 (NK-1) receptor. It serves as a valuable tool for researchers and developers in the pharmaceutical and biotechnology sectors, enabling precise investigation of peptide-receptor interactions, signal transduction pathways, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a potent and stable NK-1 receptor ligand for studying pain signaling, inflammation, and emotional regulation pathways.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and structure-activity relationship (SAR) studies to design new neurokinin receptor antagonists.
• Biochemical Assays: Employed in competitive binding assays, receptor autoradiography, and functional cellular assays to characterize receptor affinity and efficacy.
• Photaffinity Labeling: The incorporated Bpa (biphenylalanine) moiety can serve as a photaffinity probe for cross-linking studies to map receptor binding sites.
• Academic & Institutional Research: A key reagent for universities and research institutes exploring the role of Substance P in various physiological and pathological processes.
• Peptide Chemistry Reference Standard: Used as a reference compound for analytical method development and validation in peptide synthesis and purification.

Basic Information

Product Name	Substance P, Bpa(8)-
CAS No.	130409-05-1
Molecular Formula	C78H111N21O13S
Molecular Weight	1590.9 g/mol
Synonyms	[p-Bpa8]-Substance P; Bpa8-Substance P; [Biphenylalanine8]-Substance P; Arg-Pro-Lys-Pro-Gln-Gln-Phe-p-Bpa-Gly-Leu-Met-NH2; Modified Substance P analog; NK-1 receptor ligand analog; Photolabile Substance P derivative
EINECS	Contact for details

Quality Control

Our Substance P, Bpa(8)- is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and MS for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as purity, peptide content, and solvent residues. Our quality system is designed to support research and development requiring reliable, high-quality bioactive peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Solvent Residues	Meets ICH guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.