Description

n-Boc-Benzotriazole is a protected derivative of benzotriazole, a versatile heterocyclic compound widely used as a synthetic building block and protecting group reagent. This compound is critical for enabling complex multi-step organic syntheses, particularly in the development of pharmaceuticals and advanced materials, by providing a stable, orthogonal protecting group for amines. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, reliable reagents for peptide synthesis and the preparation of complex organic molecules.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the Boc-protecting group onto amine functionalities in peptide and small molecule drug candidates.
• Peptide Synthesis: Used extensively in solid-phase and solution-phase peptide synthesis to protect amino acids, preventing unwanted side reactions during coupling steps.
• Organic Synthesis Building Block: Serves as a versatile precursor for constructing more complex heterocyclic systems and functionalized benzotriazole derivatives used in material science.
• Agrochemical Research: Employed in the research and development of novel herbicides, fungicides, and insecticides where protected amine intermediates are required.
• Material Science: Utilized in the synthesis of polymers, ligands for catalysis, and organic electronic materials that incorporate benzotriazole motifs for their electronic or coordinating properties.
• Chemical Biology & Proteomics: Acts as a tool compound for labeling and modifying biomolecules in research applications exploring protein function and interaction.

Basic Information

Item	Detail
Product Name	n-Boc-Benzotriazole
CAS No.	130384-98-4
Molecular Formula	C11H13N3O2
Molecular Weight	219.24 g/mol
Synonyms	1-[(tert-Butoxy)carbonyl]-1H-benzotriazole; 1-Boc-benzotriazole; tert-Butyl benzotriazole-1-carboxylate; N-Boc-benzotriazole; 1H-Benzotriazole, 1-[(1,1-dimethylethoxy)carbonyl]-; Boc-benzotriazole; Bt-Boc; Benzotriazol-1-yl tert-butyl carbonate
EINECS	Contact for details

Quality Control

Our n-Boc-Benzotriazole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.