Description

Ibutilide is a potent class III antiarrhythmic agent, a crucial pharmaceutical intermediate and active pharmaceutical ingredient (API) used in the synthesis of advanced cardiac medications. Its primary value lies in its specific mechanism of action for the acute termination of atrial fibrillation and atrial flutter, making it a key component in life-saving drug formulations. This compound is essential for pharmaceutical manufacturers, research institutions, and chemical suppliers serving the global cardiovascular drug market. High-purity Ibutilide is fundamental for ensuring the efficacy and safety of the final medicinal product.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in injectable formulations for the rapid conversion of recent-onset atrial fibrillation and flutter.
• Cardiovascular Research: A critical reference standard and tool compound for studying cardiac ion channels (particularly the rapid component of the delayed rectifier potassium current, IKr) and arrhythmia mechanisms.
• Process Development & Scale-up: Serves as a key intermediate for chemical process R&D teams optimizing synthetic routes for commercial manufacturing.
• Analytical Standard: Used in quality control laboratories as a high-purity reference material for HPLC, LC-MS, and NMR method development and validation.
• Generic Drug Manufacturing: Sourced by manufacturers developing bioequivalent versions of branded antiarrhythmic drugs.
• Preclinical & Clinical Trial Material: Supplied as GMP-grade material for non-clinical studies and clinical trial batch production.

Basic Information

Product Name	Ibutilide
CAS No.	130350-52-6
Molecular Formula	C20H36N2O3S
Molecular Weight	384.58 g/mol
Synonyms	Ibutilide fumarate; U-70226E; (4R)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide; (+)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide; Ibutilide (base); Corvert (brand name); 4-[4-(Ethyloctylamino)-1-hydroxybutyl]phenyl]methanesulfonamide (related form)
EINECS	Contact for details

Quality Control

Our Ibutilide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for pharmaceutical R&D and manufacturing. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters are available for every lot. Our quality systems are designed to support requirements for GMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under controlled room temperature conditions (typically 15-25°C) in a dry environment. For long-term storage, consider holding under inert atmosphere to maximize stability. Keep container tightly sealed when not in use to protect against moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.